Sublingual immunotherapy with allergenic extract of Valergen mites in children with Bronchial Asthma sensitized ( Original ).
Keywords:
asthma; sublingual immunotherapy; allergenic extracts; cutaneous reactivenessAbstract
Bronchial asthma is considered a health problem, by its high frequency, its economic impact and repercussion in life quality. The objective of the research is to evaluate the effectiveness of the sublingual immunotherapy with allergenic extracts of Valergen mites in children with Bronchial Asthma sensitized in the University Policlinic “Juan Miguel Martínez Puentes “,from the north health area from municipality Sancti Spíritus, between February 2019 and February 2021. A development research, with a quasi-experimental design of therapeutic intervention in 25 patients (between five and 15 years) who were sensitized to Valergen allergenic extracts was made. These patients were attended in the Allergology consultation in the University Policlinic “Juan Manuel Martínez Puentes”. The recommendations of the manufacturer were followed. The effectiveness of treatment was evaluated after a year of treatment. Clinical and sociodemographic variables were included. Results were expressed in absolute and relative frequency and methods of statistical significance were applied too. The major frequency was in male sex (76 %), the age between five to nine years (44 %) and associated to allergic rhinitis (40%). Dermatophagoides siboney mites prevailed with 12 patients. Cutaneous reactiveness decreased (77, 7%) (p=0.012). The male sex prevailed and the most affected ages were between five and nine years. The association with allergic rhinitis and the sensitization to Dermatophagoides siboney prevailed. There were an improvement of the symptoms in more than a third part of patients.
Downloads
References
Abou Khair. F., Rodríguez, S. O. y Labrada, R. A. (2010). Prueba cutánea de Prick Test con extractos estandarizados de ácaros de diferente procedencia, en niños con asma y rinitis alérgica. Revista de Alergia, Asma e Inmunología Pediátricas, 19(3), p.p. 77-80. https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=31843
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., y Zar, H. J. (2008). Global strategy for asthma management and prevention: GINA executive summary. European Respiratory Journal, 31(1), 143-178 https://erj.ersjournals.com/content/31/1/143
Bousquet, J., Scheinmann, P., Guinnepain, M. T., Sauvaget, J., Tonnel, A. B., Pauli, G. D., Caillaud, R., Dubost, F., Leynadier, D., Vervloet, D., Herman, S., Galvain, S., & Andre, C. (2001, diciembre 24). Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1398-995.1999.00916.x
Carnés, J., Iraola, V., Seon, H., & Esch, R. B. (2017). Mite Allergen Extracts and Clinical Practice. Ann Allergy. Asthma Immunol, 118(3), p.p. 249-256. https://pesquisa.bvsalud.org/portal/resource/en/med-15576
Cortez, K. F., Martínez, N. I., & Vázquez, G. (2017). Factores que inciden en el Asma bronquial en niños menores de doce años. Universidad Estatal de Milagro http://repositorio.unemi.edu.ec/handle/123456789/3744
Fuentes, Y., Castro, R., Rodríguez, R., Martínez, I., & Labrada, A. (2008). Eficiencia de dos pruebas diagnósticas en la determinación de alergia por ácaros en niños. Revista Vaccimonitor, 17(2), p.p. 14-44. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=s1025028x2008000200001
Guo, Y., Li, Y., Wang, D., Liu, Q., & Hu, L. (2017). A randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. Am Rhinol Allergy, 31(4), 42-47. https://pubmed.ncbi.nlm.nih.gov/28716168/
Kasayuki, N., & Makoto, N. (2021). Allergen immunotherapy for asthma. Pathongens, 10(11), 12 -24. doi: 10.3390/pathogens10111406
Martínez, N., Aranda, R.E., Casas, R., Garriga, S., & Labrada, A. (1997). Epidemiological study of sensitization to common inhalant allergens in Cuba. Allergy and Clinical Immunology, 13(4), 48-68. DOI: 10.13140/RG.2.2.23208.62
Molina, M., Ramírez, G., & Ross, P. (2015). Evolución clínica de pacientes asmáticos tratados con inmunoterapia. Municipio Majibacoa, 2008-2013. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 38(8), 12-38. http://revzoilomarinello.sld.cu/index.php/zmv/article/view/484
Oksel, C., & Custovic, A. (2018). Development of allergic sensitization and its relevance to pediatric asthma. Current opinion in allergy and clinical immunology, 18(2), 109-116. https://pubmed.ncbi.nlm.nih.gov/29389732/
Pagés, R., Calderín, M., & Morales, M. (2017). Vigilancia de la efectividad y seguridad de las vacunas VALERGEN en el tratamiento del asma. Revista Archivo Médico de Camagüey, 20(6), 12- 44. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S102502552016000600007&lng=es
Rodríguez, O., Murillo R. C., Laurrabaquio, A. M., & Cruz, M. A. (2015). Eficacia y seguridad de la inmunoterapia con extractos de ácaros en rinoconjuntivitis alérgica y en asma bronquial. Archivos de Alergia e Inmunología Clínica, 46(1), 15-19. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-916117
Sienra, J. J. L., Maureen, E., Navarrete, E., Chávez, Flores, U., Lezana, M. A., Baeza, R. A., Baeza, M. A., Escalante, A. J., Escalante, A. J., Macías, A., & Meneses, F. (2019). Anafilaxia en niños y adultos: prevención, diagnóstico y tratamiento. Revista Conamed, 24(3), 107-164. https://www.medigraphic.com/pdfs/conamed/con-2019/con193a.pdf
Yepes, J. J., Gómez, C., Espinoza, Y., & Cardona, R. (2014). Impacto de la inmunoterapia subcutánea con Dermatophagoides farinae y Dermatophagoides pteronyssinus sobre la calidad de vida de pacientes con rinitis y asma alérgica. Revista Biomédica, 34(2), 12-44. https://revistabiomedica.org/index.php/biomedica/article/view/1744
Published
Issue
Section
License
Copyright (c) 2024 Roca. Scientific-educational publication
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
